Cancer is a major human health problem worldwide and is the second leading cause of death in the United States (1). Over the past 30 years, significant progress has been achieved in understanding the molecular basis of cancer. The accumulation of this basic knowledge has established that cancer is a variety of distinct diseases and that defective genes cause these diseases. Further, gene defects are diverse in nature and can involve either loss or gain of gene functions. A number of inherited syndromes associated with increased risk of cancer have been identified. This chapter will review our current understanding of the mechanisms of cancer development, or carcinogenesis, and the genetic basis of cancer. The roles of gene defects in both
germline and somatic cells will be discussed as they relate to genetic and sporadic forms of cancer. Specific examples of oncogenes, or cancer- causing genes, and tumor suppressor genes will be presented, along with descriptions of the relevant pathways that signal normal and cancer phenotypes.
This ebook can be download at:
http://www.4shared.com/account/file/180834044/57ebc111/Burgers_Medicinal_chemistry_an.html
0 komentar:
Posting Komentar